# Registering with COMS The Committee on Microbiological Safety (COMS) use [e-COMS](https://compliance.hms.harvard.edu/COMSIACUC) (online system) to submit all new protocols, 5-year rewrites, annual renewals and amendments for research projects involving COMS-Regulated Materials ([CRM](/file_url/254)) and specific materials. COMS Regulated Materials (CRM) are defined as: • Recombinant or synthetic nucleic acids as defined in the NIH Guidelines • Human or nonhuman primate blood, cells, tissues, fluids, and secretions • Biological toxins subject to the National Select Agent Registry Program; and • Bacteria, viruses, fungi, parasitic protozoa, and prions. [2026 COMS Meeting Schedule](/sites/g/files/omnuum5351/files/2025-10/2026%20COMS%20Meeting%20Schedule%20Final.pdf "2026 COMS Meeting Schedule") For protocol submission deadlines, please contact your institutional biosafety officer. If you have a question pertaining to whether a COMS registration is required based on the nature of your research and/or materials involved please email . BSOs can provide guidance on protocol submittal to PIs and designees. For more information about registering with COMS please contact your Biosafety Officer: [**Harvard Allston, Cambridge, and, Longwood Campuses**](https://www.ehs.harvard.edu/safety-officers) Harvard University Biosafety Office **Joslin Diabetes Center** Michael Melisi **WYSS Institute for Biologically Inspired Engineering at Harvard University** Robert Rasmussen [Robert.Rasmussen@wyss.harvard.edu](mailto:mailto:Robert.Rasmussen@wyss.harvard.edu)